JADA August 2017
The effectiveness of management strategies used for the treatment of
medication-related osteonecrosis of the jaw (MRONJ) remains poorly understood.
The authors evaluated systematically the effectiveness of the various treatment
modalities used for MRONJ. The authors conducted a comprehensive search of
MEDLINE, Embase, the Cochrane Library, and Scopus to identify randomized
controlled trials, nonrandomized controlled trials, and prospective cohort
studies to evaluate comparatively the effectiveness of management strategies for
the treatment of MRONJ. The authors conducted the identification of eligible
studies in duplicate and synthesized the extracted data by means of a
metaanalysis, when feasible.