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A case-control study of topical and supplemental fluoride use and osteosarcoma risk (May 2021 Article 1)
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JADA May 2021

Background. A relationship between fluoride and osteosarcoma has been hypothesized but not validated. To the authors’ knowledge, there are no published studies examining topical fluoride or dietary fluoride supplements and osteosarcoma risk. The purpose of this study was to examine the association between ever or never use of topical and dietary fluoride supplements and osteosarcoma.

Keywords.Topical fluoride; fluoride supplements; osteosarcoma; case-control.